FWIW, two years ago, I bought a B/CCH .45 Colt New Vaquero (new) that shot factory ammo right to the sights @ 7yds (21') - the distance I was interested in shooting it.
I've owned Ruger BH .45 convertibles (OM & NM) - which needed sight changes/correction/adj when changing cylinders/ammo.
I thought it more trouble than it was worth, and that I'd rather have two separate guns, one in .45 Colt, and a 2nd in .45ACP.
YMMV, of course.
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