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Yes, it can be done IF you have the revolver machined to take moon clips, or it is one of the few revolvers having a special extractor that can support rimless cartridges. Other tricks are possible, but not really practical.
.380 standard pressure is 21,500 psi, about the same as .38 Special +P, but there are fewer square inches, so the total pressure is in the .38 Special range.
Since .38 Special is widely available and still reasonably cheap, and .380 ACP is hard to get and expensive, the question is rather hypothetical. Revolvers made for the 9mm Parabellum were mainly for foreign police agencies who wanted revolvers for PR reasons, but wanted to be able to use the free 9mm ammo provided by the military.
Jim
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