[Brian Pfleuger]

.22-250 and .204 ruger will be VERY flat shooting and more than capable of 400+ yard shots. If you intend to shoot that distance at deer size targets you'll need something bigger. The 30 caliber guns are pretty severe overkill on those smaller animals. Something like a .25-06 might make a good compromise.
If it's a "Gee, maybe someday I might shoot a deer, maybe." then I'd just say "No, I won't." and get the .204ruger. The balllistics are incredible and it'll be easy one shot kills on most anything coyote and smaller (explosive type kills on the praire dog size).