Roll my own .41 Magnum snake shot. I have shot "at" 7 rattlers with 7 rounds and I have collected 7 sets of rattles. Distances from 8 to 20 feet. They twitched for hours, but never left the spot they were at when they received the payload.
I once unloaded 15 rounds of .40 S&W at two rattlers, close range and killed neither.
I use a pistol powder, .410 stumpbuster wad, #9 shot and a .410 overshot card with a heavy roll crimp. I did hop them up a tad with reformed .414 SuperMag cases to test out. The added effort really provided little extra benefit to the velocity or pattern.
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