My father's comment about the going-away shot was, "If you see his horns stuck out way past his butt, either side, you better take what you can get."
I sure wouldn't take that shot on a meat-doe.
With my .243 loads, a frontal shot isn't a problem. The bullet pretty well starts coming apart on the breast bone, and all there is inside is a double-handful of mush where the heart/lungs used to be. I've never had any fragments get past the diaphragm.
, Art