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Say someone is wearing body armor, perhaps behind a brick wal, blow a hole through it, or rearrange the internal organs from shear impact, or both, I think you get the point...
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Sounds like you need a RPG.
Seriously, as PawPaw said above it's still just a shotgun and will work as well as any other with the known performers. I'd stick with a good 00 buck load and be done with it.