There are no advantages to a small revolver as house gun. I would go with a K or L frame full size .357, as JimmyR suggested, or an N frame .44 or .45; or, I would go with a mid or full size service pistol (such as a G19) for capacity.
Medium and large guns are easier to shoot. The only reason to go with small revolvers or very small autos is for ease of carry - and even then, some of us stick with midsize for the most part.
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