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What about like real rifle rounds. Like 223, 243.
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http://ballisticsbytheinch.com/223rifle.html
Others have already alluded to this, but here is some data to back it up. Out of typical CC barrel lengths, you'd lose half the velocity or more (compared to .223 rifles). Auto pistol cartridges such as Sig .357 can just about match--or even surpass--those velocities with bullets 2 or 3 times heavier.
http://ballisticsbytheinch.com/357sig.html