[Kreyzhorse]

My hunting buddy uses his .375 occasionally for whitetail here in Kentucky. I have seen him take a doe with with it at 75 yards or so. The doe was hit a bit high on a broad side shot but she was dead before she hit the ground. The bullet entered her about two inches above her lungs and literally blew a tunnel threw her the size of a $.50 piece. I believe he used Remington 270gr Soft Points which I believe was the lightest he could find.

Is the .375 a bit big for whitetail? Matter of opinion I suppose but I didn't find the damage any worse than some deer I've seen in the back of hunter's trucks. I don't know if you hand load, but I would think you could really dial up some very nice whitetail rounds if you do.

I say if you want to hunt with one and don't mind the recoil, by all means do so. It might leave a bigger exit wound but you certainly won't vaporize half your deer.