Thanks all, for your input.
I'll be heading to the range this weekend, and I think I'm going to try a few things to help isolate this problem.
My main 45 ACP problems came when I bought this P97 Ruger. I'm starting to think that perhaps it's got a little tighter chamber than my Colt Commander had.
I miss that gun.
As for the 38's, it's got me, the main reason I started taper crimping was to help eliminate this problem. It did help some, but even after that I still had some issues.