On all the "regular" Smith & Wesson revolvers...they can get locked up like a bank vault if anything gets jammed under the ejector star in the cylinder. The whole thing is a very precise fit and a little foreign material under there that keeps the ejector from sitting flush will make the whole thing bind in a mindblowing fashion.
This also happens when the ejector rod loosens.
The ejector on an X-frame is a totally different design than is typical on the normal S&W revolvers, but it too can come unwound.
See if there is any way you can carefully manipulate that ejector rod. It it's unscrewing itself it leaves no room to open/close or rotate that cylinder.
This may not be your issue, but it's the first thing I'd look for.
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After dying a little bit inside
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It was kind of tough even just to
read it, I can imagine your horror.