I would think it depend upon each particular log, and your druthers, regarding how the finish grip will look.
If the grip blank is taken fron one side of a log, I would think it would be unlikely to get matching grain on both sides of the finished grip.
But
If a center cut, a particular log's core may/may not be suitable for grips, in either color, grain, or density.
I would cut out a few, using both methods, and choose - using the rest for practice (fitting/inletting & outer shaping) before doing the final/finish grip (It's not as easy as it looks).
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