I don't know about self-defense, but No 1 buck is all I've ever used for deer hunting. Every deer I ever shot with Number 1 went down and stayed down. If they required a second shot it was a "kill shot" for an animal down, and breathing it's last.
My theory is exactly what's stated above. I'd rather have 21-24, .30 cal shot in the pattern than 12-15, .33 cal, 00's (2 3/4" to 3" Magnum). 000's numbers are even fewer. Dropping down to number 4, what you gain in numbers, you lose in mass.
I admit my "theory" isn't scientific. It's based on talking to the old timers I used to hunt with and on my own experiences. Number 1 buck is good stuff.
At self-defense ranges, I doubt it really matters.
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