WESHOOT2
With the sole exception of the .45acp load you cited, all the loads you prefer are fairly high velocity.
I don't think anybody will argue for low velocity rounds, for most purposes. (Although for hunting, heavier, slower rounds tend to do the job while wrecking less meat.)
But if a 125gr at 1220fps will do the job, then a 158gr at 1220fps should definitely do the job, and should penetrate deeper. Assuming similar velocities and comparable metallurgy, expansion should also be similar.
More penetration may or may not be desirable.
But the snark wasn't necessary, nor helpful.
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