Depends on how you hold your gun. I think they would be fine. I would go to a fun store and hold one that already has them installed, before spending that spending that kind of money.
I'd bet there are lefties here that will be along shortly with a definitive answer.
If they don't work for left handed shooters Crimson Trace is losing a great number of potential customers.
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When I was a boy of fourteen, my father was so ignorant I could hardly stand to have the old man around. But when I got to be twenty-one, I was astonished by how much he'd learned in seven years. ~Mark Twain
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