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Again, it's your gun and you can do what you like but I'll reiterate that 325 gr at 1200 fps isn't going to be healthy for a S&W M25. If that's the kind of ammo you want to shoot, I'd suggest that you consider trading it for a Ruger Redhawk in .45 Long Colt as it's better suited to that sort of ammunition and doesn't have any locks to begin with.
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I have a Super Redhawk in 454 Casull. I wanted something a bit lighter that still packed a punch. After a lot of research, I decided on a Model 25, and it doesn't disappoint. And it is noticeably more accurate than my SRH 454 as well.