I'm a lefty who is right eye dominant. I've shot right handed SG's and rifles most of my life, but now have two Ithica 37's (20 & 12) and a couple rifles that have had the safeties switched to the "correct" side. Like most lefties though, I've learned to adapt and it really doesn't matter what I shoot. I'm equally bad with everything!
I used to have an American Arms 20 gauge O/U that would be perfect for most women, regardless of left or right mindedness. They are nice guns and are reasonably priced. Good luck.