I don't have a handgun for home defense. I have about half a dozen, discretely dispersed about my premises. I am never more than a few feet from one or another. They are all revolvers. Calibers include .38Spcl/.357Mag, .44 Special, .44Magnum, .45 Colt, and .45ACP. Their intended role is to defend myself on the way to my closet where a very handy AK47 Underfolder and a Remington 1100 await.
All are on a regular rotation for trips to the range.