Several of my fingers are twisted 90*. Makes typing a beech among other things. I've had carpal surgery on both hands and severe problems with both shoulders.
I don't shoot 44 mags nearly as much as I used to for sure. My suggestion is to keep looking for grips that are comfortable as whatever happens with the hands progresses. I just added some "traction tape" to my carry pistol grip to aid in a positive grip. Most of my revolvers have some type of softish rubber grips with Hogue being preferred.