First of all, I suffer from osteo-arthritis which is not the bone twisting rhumatoid arthritis. It is often uncomfortable, but not a killer like RA.
My favorite pistol is an STI Trojan in 9mm. I shoot a 125 cast bullet over 4.0 grs 231 with a 9 pound spring. It is mild and allows range sessions of over a hundred rounds before I am reminded to quit.
Using a heavy handgun with light recoil allows me to continue shooting handguns.
A .22 rf in a Ruger 22/45 is great but I can't afford rim fire ammo comparted to casting and reloading 9mm.