It varies as I do rotate a few in and out.
My normal to go night stand pistol is a plain Jane black P220 .45 with night sights and slim grips. I keep one in the chamber, full mag, and a spare mag ready to go.
At other time I will have model 19 S&W .357, Sar K2 .45, FNP-45, 1911, or what ever else strikes my fancy.
Also I have a 12 gauge shotgun close by loaded with 00 buck.