Definitely not worth the trouble. The gun is made as a centerfire, the magazine made for semi rim/rimless ammo, whereas 22lr is rimmed. The extractor is for the same cartridge aka not a rimmed cartridge. I would have to think getting it to work reliably could be an effort. Depending on the 22lr ammo, the recoil spring could need tweaked or replaced. There are a lot of issues with such a project.
Even if it was easier to convert, what would you have when you are done? Nothing really. As a pocket pistol, the 25 auto offers many benefits over a 22lr. In addition, this conversion would devalue the gun, meaning you would never see a dollar for all the effort that the conversion would take. There are better expenditures of your time, gun wise.
Winchester 73, the TFL user that won the west