I have a GP-100 in 6" I use it for everything as the opportunity arises. I keep it loaded at home and when I carry it with Hornady Critical Defense. I practice with about anything I can get plus some hand loads that I am getting into. the GP-100 is heavy so I suggest strengthening your arm for holding it up. I use a 10 pound dumbbell and hold my arm out straight until it burns too much to keep up, it makes holding the revolver out for extended periods a lot easier.
There is no such thing as Overkill, Dead is Dead!