My understanding is that a GP100 will be preferred if you intend to handload as, in the case of a catastrophic failure, the Ruger will handle it while the Smith may not.
Nothing personal and sticking entirely to the subject, I have never seen anything that would even HINT at this statement being accurate.
I would further say that anyone who picks a particular handgun over any other due in part because they fear blowing up a handgun with their handloads...should never
attempt to handload. Ever. Please.