Best .45 defensive ammo
My honest opinion is that any of the top shelf ammo from one of the major producers will serve well. Remington golden sabers, Winchester PDX, Hornady critical defense, Speer gold dots, Federal HST; they're all good stuff.
Then there's the "boutique" ammo from Cor-Bon, Double Tap, Buffalo Bore, etc. I'm sure it's good, too. But I don't know if its performance justifies the extra cost.