LCR in .40S&W, 10mm or 9x19mm...
A +P rated 9mm(9x19mm) or .40S&W/10mm Ruger LCR could have a lot of interest in the USA. Semi auto pistols are extremely popular & a LCR BUG(back up gun) or as a 2nd gun could get a lot of support.
Charter Arms & Taurus USA put out small frame snubs in .40 & 9mm so it can be done.
Ruger could get a big part of the concealed carry market for armed professionals or license holders who want a revolver back up for a .40S&W or 9x19mm sidearm.