I have large size hands and one of my favorite carry pistols in the Sig
P-245, a six plus 1 .45 ACP compact. It's new version is called the 220-compact. It's light, accurate and reliable
Is this the gun you are talking about?:
I would definitely consider it because a Sig P22X was high on the list for my next gun. So you find it easy to carry? Very interesting if so...