I have a 22/45 with a cheap red dot. Great little shooter and very accurate. Easy to use out to 100yds, 10rnd 4" grps with a flyer. There are RD's with 2x mag available and that may be a good choice for you. I also have a 460xvr with a Weaver 4x on top. I would I plan to be shooting this more in the 50-150 range. Nice fine cross that doesnt cover the target up. I like the idea of a 2-7x but the problem is that they are large and heavy. By time you get a mount, rail and scope you would be surprised how much weight goes on the gun. If you plan to be 50 with an occasional 100yd I would lean toward a RD.
Concentrated power is not rendered harmless by the good intentions of those who create it.