For me and my .44 Magnums (5 of them), Unique is much more versatile. H110/W296 is full out Magnum loads only, no reduction of charges is recommended. I can get magnum velocities and also easy shooting "Special" level loads with Unique. Since I have found that full out, near max. loads aren't necessarily the most accurate, and any animal I shoot wouldn't be able to tell if my 250 gr. LSWC is going only 1100 fps rather than 1400, I'll stay with Unique (of the two you mention).
jes my thoughts...
My Anchor is holding fast!