My basic accuracy standard for service autos is 4" at 50 yards, for five shots from a rest. I expect a good centerfire revolver to shoot better but to tell the truth, I have a hard time holding any closer than that.
For better than 40 years, I've been able to meet that standard with untrimmed pistol brass in both autos and revolvers. If I were shooting for money or trophies, I'd take every precaution to insure the consistency necessary for 10 shots in 2" at 50.
Nick raises a good point about getting your seating depth just right with 45 SWC's. Assuming a close copy of the H&G #68, I have run them at 1.250" for decades with good accuracy in a number of guns- and boring reliability.
“Nine-tenths of tactics are certain, and taught in books: but the irrational tenth is like the kingfisher flashing across the pool, and that is the test of generals. It can only be ensured by instinct, sharpened by thought practicing the stroke so often that at the crisis it is as natural as a reflex.” ~ T. E. Lawrence