My basic accuracy standard for service autos is 4" at 50 yards, for five shots from a rest. I expect a good centerfire revolver to shoot better but to tell the truth, I have a hard time holding any closer than that.
For better than 40 years, I've been able to meet that standard with untrimmed pistol brass in both autos and revolvers. If I were shooting for money or trophies, I'd take every precaution to insure the consistency necessary for 10 shots in 2" at 50.
Nick raises a good point about getting your seating depth just right with 45 SWC's. Assuming a close copy of the H&G #68, I have run them at 1.250" for decades with good accuracy in a number of guns- and boring reliability.