I'm a big fan of light, fast bullets. I almost always use the lightest bullet that will do the job.
Folks talk about 55+ grain 22-250 bullet being "flat shooting". You ain't seen flat until you've seen a 35gr Nosler LF at 4,435fps.
There's another consideration too. Twist rate effects velocity. It's harder to push a bullet in tight rifling. The difference between really tight, like 1:8, versus 1:12 could be a hundred fps.
Still happily answering to the call-sign Peetza.
The problem, as you so eloquently put it, is choice.
He is no fool who gives what he can not keep to gain what he can not lose.
-Jim Eliott, paraphrasing Philip Henry.