No difference in strength. I have one in .45 ACP and I also handload the .45 Super. I've not tried any .45 Super in it yet, but I don't see that it would be a problem as my .45 Super loads are at least 30K psi loads if not more.
There's an article about a guy using the .45 ACP cylinder and ACP brass to load up 460 Rowland level loads and it worked. I'm not advocating that, but just to say it's been done.
Glocks and Single Actions