I had a .22-250 model 700 re-barreled a couple of years ago and swore I'd never do it again, due to the cost and amount of time it took to get it back. The reason for the rebarrel is that the rifle had sentimental valued, but I wanted to have it in .243 Win, which is more useful in my present situation and for grandkids to hunt deer.
The rifle doesn't shoot as well as it did as a .22-250, but it's a great hunting rifle now. I use it for coyotes a fair amount, though have a new Tikka T3 Lite that is a better walkabout rifle.
The cost difference between selling the rifle and getting a T3 was more money for the re-barrel...about $150 more. The time without the rifle was excruciating!!!
People are like rifles. Some are tried and true, having great eyes, personality, and fun to be with. Others never seem to hit the mark with you. Still others go off half-cocked. Still, it's nice to know most of them.