My favorite do all caliber is .45 Colt which has been on the job since 1873. My favorite revolver at the moment is my medium frame Ruger flattop convertable 5 1/2" from Lipseys. Just right. Was out shooting it yesterday. Just something about .45 Colt that I just can't get enough of.
It is a reloader's cartridge though to get the most benifit.
A clinger. When guns are outlawed, only outlaws will have guns. Single Action .45 Colt (Sometimes improperly referred to by its alias as the .45 'Long' Colt or .45LC). Don't leave home without it. Ok.... the .44Spec is growing on me ... but the .45 Colt is still king.