I love the 45 Colt. I have a Ruger Blackhawk and Rossi 92 chambered for it and hunt occasionally with them. The only drawback is the cost of ammo. For me it is a handloaders dream cartridge. Cowboy loads are pleasant to shoot and actually make pretty good SD loads. Loaded hot it is a hoot to shoot and will knock heck out of anything here in Texas.
I say jump in with both feet. You won't regret it.