My S&W 640 is much more fun wand accurate with 38s. My Coonan Classic is more fun and accurate with 357 magnums. My Marlin also likes 357 magnums.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 25 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple