I always recommend against this. If a firearm has a safety, incorporate it into your use of the weapon. Murphy's Law loves to bite people in the butt when they least expect it.
So, for a CZ 75B, you would recommend carrying cocked and locked, rather than hammer down and double action first shot? My SW 3913 is SA/DA and has a safety/decocker. Am I not supposed to carry it hammer down with safety off like all the police did when they were carrying third gen Smiths? It seems to me that sometimes it's entirely appropriate to ignore the safety on a gun.