As far as I'm concerned it's all about shot placement - a solid hit (or several) is far and away better than a loud miss. If one can shoot thier round of choice quickly and accurately the effectiveness of the round becomes secondary. Many thousands of people have been killed with all sorts of bullet designs; I'm sure they'd still be dead whether they new the round that got them was less effective than another one.
"Don't pick a fight with an old man. If he's too old to fight, he'll just kill you."