When I'm shooting steel with my 22/45, I have to slide my hand around to the right in order to get the gun to come up with the sights aligned on the target. On Smoke & Hope, I can usually get the first shot off in about 0.40 sec, but only if I'm gripping the gun correctly. With the right grip, the gun will shoot where you look on the first 4 targets and be damn close on the stop plate.
Take your time and get your grip right before "shooter ready". The RO will wait for you. Not that he has a whole lot of choice.