Mleake, in the hands of someone who knows what they are doing, yes a knife is a much more formidable weapon (why I use one instead of a skillet). However, I would bet that those of us that know how to use knives in defense and counter other hand attacks are in the minority.
I am smaller, and don't have the raw physical strength of some. I would expect that if someone were to attack me they would have at least 50 lbs and about 5" on me. For me, finding an opportunity to get inside of an assailants arm reach quick enough to deliver a couple stabs and slashes and then getting out is the name of the game. Make hits where they count, and counter your opponents attacks... But you know what they say about plans