There's always a trade-off between velocity, and heavier, high-BC bullets.
At long range (past the 500-600 you're referring to) I give the nod to the high BC bullets as they're less affected by wind drift despite the longer flight time, just my personal experience.
I always experiment...you will need to see what your rifle/barrel likes- every one is different. That's what load development is for...
07 FFL /Mosin-Nagant Custom Shop/Bent Bolts
Gun-Kote/ Cerakote Refinishing
Criterion Barrels/ Savage Re-Barreling