If there was a gunfight I'd run away from it.
If I had to defend myself with a gun I'd want a Colt 6940 with iron sights.
If it had to be a handgun, I'd pick 1911 45 ACP--preferably a series 70 in full 5".
If I had to carry it all day long, I'd go to a 4.25" Commander.
If I wanted more bullets for some reason, I'd get a 9mm Hi-Power or a P226.
If for some reason I was told I had no option but to carry a gun that fits in the pocket of my pants, wasn't allowed to wear loose clothing, a holster, or a belt, I'd go with a 380.