My preference might be to have multiple, loaded firearms rather than to have to reload in the event of a confrontation. Or I might prefer to keep a firearm in each of several rooms rather than carry a gun from room to room. That's my plan for self-defense.
Mine, too. Currently, multiple loaded handguns, a shotgun with rounds in the tube but not chambered, and an AR-15 located in close proximity to a loaded 20-round mag. As the fella' said, "If I get killed, it won't be for lack of ammo."