I have 2 of the old Beretta Minxes (Model 950) chambered in .22 short. I don't carry them, but they are fun to plink with. The first was inherited after my dad passed away- he kept it as a carry pistol in a leather bank bag while at craft shows. The second was a 4" model I found after some scouring, and decided to add it to the collection.
Again, to answer the OP, I would personally not use them for personal defense unless nothing else was available. I have been getting .22 short Remington High Velocity rounds for fairly cheap, so they end up being fun plinkers.