Do not confuse lethality with incapacitation. Many more people that were shot died from the ensuing infection than the effects of the bullet. Penicillin was not truly discovered until 1928 and not mass produced until 1945.
I don't know about you, but if I must shoot in self defense I do not look forward to the infection being a determining cause of incapacitation.
This subject has been discussed before ad-nausium.
My rifle and pistol are tools, I am the weapon.