I have had experience with only one such revolver, a Ruger Three Screw Super Single Six.
I used the magnum cylinder often, using the old .22 WRF cartridges for squirrel hunting. At times loaded up with .22 WMR for pests, crows etc.
I only occassionally used the L.R. cylinder, and not so much for fine target work as general plinking. If I lost any accuracy, it was not apparent to me.