Yes...I have two Dillon 550B's for reloading hand gun ammunition. One is permanently set for small pistol primers and the other for large. Each press also has its dedicated Dillon powder measure. This setup minimizes caliber change time and after 50+ years of reloading, I figgur I'm worth it!
For rifle, I use an RCBS Uniflow with both big and small micrometer drops.
Our Flag does not fly because the wind blows against it,
It proudly waves because a soldier's dying breath blows upon it.
USAF Forward Air Controller, 5th Spl Forces,
An Loc, lll Corps, RVN, 69-70, Vietnam Vet '69-'73