From my experience if you set your sights for target range practice, the setting is non-effective when shooting tactical.
I would put up some larger targets to see if you are shooting hi,low, left, or right more often and adjust the sights accordingly.
Worked for me, just had to compensate at the range where i still shoot.
Seems that sight picture is different for me on the move than standing still.
Furthermore are you on foot or machine? what stance do you use?
The weaver is fine for just target practice but the isosceles stance is better for movement and moving target. Good luck!