Proficiency is everything. If you are more comfortable and proficient with a single action then it is a better choice than something else that 'may' be more socially acceptable to 'some' folks.
Never fan a single action revolver that is not built specifically for the purpose. It's a fast way to destroy an otherwise fine sixgun. Not a good idea in a defensive situation either.
To use a cowboy gun or single action revolver in 2013 may be difficult to explain in open court.
That's an interesting yet unsupported theory.
In the real world, Thunder Ranch and Gunsite have defensive courses designed specifically around using single action revolvers.