I am just wondering if you need to work on your Bullets more than the powder for accuracy?
I shoot lots of 158 round nose in Defensive Pistol and Steel Challenge Matches. I put the micrometer on some commercial bullets a while back that were .356. They are shooting OK, but I suspect they would not be the best for driving tacks at 50 yards.
Bullet Hardness is also an issue with accuracy.
If you do not find an answer here, you might ask about accurate bullets over on the Cast Bullet Forum Site.
I would probably look at the Semi Wadcutter Bullets instead of Round Nose for accuracy.
In my opinion you need to start with a very good bullet that is known to shoot very well, then start working on the powders.
Just My 2 Cents